Effects of green tea polyphenol extract and epigallocatechin-3-O-gallate on diabetes mellitus and diabetic complications: Recent advances
Chunpeng Wan, Jian Ouyang, Mingxi Li, Kannan R. R. Rengasamy, Zhonghua Liu
Abstract
-gallate (EGCG), which acts as a potent antioxidant. Recently, several lines of evidence have shown the promising results of GTE and EGCG for diabetes management. Here, we have critically reviewed the effects of GTE and EGCC on diabetes in animal models and clinical studies. The concerns and challenges regarding the clinical use of GTE and EGCG against diabetes are also briefly discussed. Numerous beneficial effects of green tea and its catechins, particularly EGCG, make this natural product an attractive pharmacological agent that can be further developed to treat diabetes and its complications.
Topics & Concepts
Diabetes mellitusMedicineGreen tea extractCamellia sinensisGreen teaEpigallocatechin gallateOxidative stressTraditional medicinePharmacologyPolyphenolAntioxidantInternal medicineEndocrinologyFood scienceBiologyBiochemistryBotanyTea Polyphenols and EffectsPhytochemicals and Antioxidant ActivitiesTryptophan and brain disorders