The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer
M. Ben Hammouda, Amy E. Ford, Yuan Liu, Jennifer Zhang
Abstract
The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide range of cellular processes, including cell proliferation, differentiation, survival, apoptosis, and inflammation. Dysregulation of JNK pathway is associated with a wide range of immune disorders and cancer. Our objective is to provide a review of JNK proteins and their upstream regulators and downstream effector molecules in common skin disorders, including psoriasis, dermal fibrosis, scleroderma, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma.
Topics & Concepts
Kinasep38 mitogen-activated protein kinasesCancer researchInflammationMAPK/ERK pathwayPsoriasisSignal transductionCell biologyApoptosisCancerBiologyMitogen-activated protein kinaseCell signalingImmunologyMedicineBiochemistryGeneticsMelanoma and MAPK PathwaysCutaneous Melanoma Detection and ManagementCutaneous lymphoproliferative disorders research