Electrochemical Decarboxylative Addition of <i>N</i>‐Aryl Glycines to Enaminones: Access to C3‐Aminomethyl Chromones
Siyang Han, Chengcheng Fang, Yaoge Zhang, Sifeng Li, Min Huang, Taimin Wang, Baigang An, Bin Cheng
Abstract
Abstract An electrochemical decarboxylative addition of N ‐substituted glycines to enaminones has been developed and conducted under oxidant‐, catalyst‐, and light‐free conditions in acetonitrile at room temperature by using electron as the traceless oxidant, which provided a green approach to access C3‐aminomethyl chromones. The resulting products were formed through radical addition/oxidation/cyclization or electrophilic addition/cyclization pathway and could act as valuable building blocks to construct polysubstituted pyrimidine derivatives.
Topics & Concepts
ChemistryArylElectrochemistryDecarboxylationCombinatorial chemistryOrganic chemistryMedicinal chemistryCatalysisAlkylPhysical chemistryElectrodeSynthesis of Organic CompoundsRadical Photochemical ReactionsCatalytic C–H Functionalization Methods