The polypeptide antibiotic polymyxin B acts as a pro-inflammatory irritant by preferentially targeting macrophages
Tomohiro Kagi, Rio Naganuma, Aya Inoue, Takuya Noguchi, Shuhei Hamano, Yuto Sekiguchi, Gi-Wook Hwang, Yusuke Hirata, Atsushi Matsuzawa
Topics & Concepts
InflammasomeNephrotoxicityPolymyxinHMGB1Polymyxin BCytotoxic T cellChemistryMicrobiologyInnate immune systemInflammationPyrin domainNeurotoxicityTumor necrosis factor alphaImmunologyBiologyAntibioticsImmune systemToxicityBiochemistryIn vitroOrganic chemistryInflammasome and immune disordersImmune Response and InflammationPneumocystis jirovecii pneumonia detection and treatment