Redox-Neutral Photocatalytic Radical Cascade Cyclization for the Synthesis of CH<sub>2</sub>CN/CF<sub>2</sub>COOEt/CF<sub>3</sub>-Containing Benzo[4,5]imidazo[2,1-<i>a</i>]isoquinolin-6(5<i>H</i>)-One Derivatives
Liang Liu, De‐Yong Yang, Yan‐Hong He, Zhi Guan
Abstract
A novel method for the synthesis of benzo[4,5]imidazo[2,1-a]isoquinolin derivatives via visible-light-induced radical cascade cyclization is described. By using N-methacryloyl-2-phenylbenzoimidazoles and diverse radical precursors, various benzo[4,5]imidazo[2,1-a]isoquinolin derivatives containing CH2CN/CF2COOEt/CF3 can be formed in good to excellent yields under mild reaction conditions. This method exhibits good functional group tolerance and a wide range of substrate scope.
Topics & Concepts
ChemistryPhotocatalysisRedoxRadical cyclizationSubstrate (aquarium)CascadeRadicalPhotochemistryMedicinal chemistryCatalysisOrganic chemistryOceanographyChromatographyGeologyRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques