Dasabuvir Inhibits Human Norovirus Infection in Human Intestinal Enteroids
Tsuyoshi Hayashi, Kosuke Murakami, Junki Hirano, Yoshiki Fujii, Yoko Yamaoka, Hirofumi Ohashi, Koichi Watashi, Mary K. Estes, Masamichi Muramatsu
Abstract
Although there is an urgent need to develop effective antiviral therapy directed against HuNoV infection, compound screening to identify anti-HuNoV drug candidates has not been reported so far. Using a human HIE culture system, our compound screening successfully identified dasabuvir as a novel anti-HuNoV inhibitor. Dasabuvir's inhibitory effect was also demonstrated in the cases of SARS-CoV-2 and RVA infection, highlighting the usefulness of the HIE platform for screening antiviral agents against various viruses that target the intestines.
Topics & Concepts
VirologyDasabuvirNorovirusVirusMedicineCoronavirusBiologyImmune systemMicrobiologySevere acute respiratory syndrome coronavirusOmbitasvirRitonavirAntiviral drugCoronaviridaeImmunologyBovine coronavirusHuman pathogenProtease inhibitor (pharmacology)RotavirusRespiratory infectionMurine norovirusFlavivirusRespiratory tract infectionsDrugViral gastroenteritis research and epidemiologyViral Infections and Immunology ResearchRespiratory viral infections research