Dassonmycins A and B, Polycyclic Thioalkaloids from a Marine Sponge-Derived <i>Nocardiopsis dassonvillei</i> SCSIO 40065
Xinya Zhang, Siqiang Chen, Liping Zhang, Qingbo Zhang, Wenjun Zhang, Yuchan Chen, Weimin Zhang, Haibo Zhang, Changsheng Zhang
Abstract
Two polycyclic thioalkaloides dassonmycins A (1) and B (2) were isolated from Nocardiopsis dassonvillei SCSIO 40065 associated with marine sponge Petrosia sp. Structures of 1 and 2 were elucidated by comprehensive spectroscopic analysis and confirmed by single-crystal X-ray diffraction experiments, to have a 6/6/6/6-fused tetracyclic ring featuring a naphthoquinone[2,3-e]piperazine[1,2-c]thiomorpholine scaffold. Compound 2 formed a caged core through an additional ether bridge. Both compounds exhibited moderate antibacterial and cytotoxic activities.
Topics & Concepts
SpongeChemistryStereochemistryPiperazineNaphthoquinoneRing (chemistry)EtherOrganic chemistryBiologyBotanyMarine Sponges and Natural ProductsSynthesis and Biological ActivityMicrobial Natural Products and Biosynthesis