Enantioselective C2–H Alkylation of Pyridines with 1,3-Dienes via Ni–Al Bimetallic Catalysis
Jiang‐Fei Li, Deng Pan, Hao-Rui Wang, Tao Zhang, Yi Li, Genping Huang, Mengchun Ye
Abstract
A chiral phosphine oxide-ligated Ni-Al bimetallic catalyst was used to realize an enantioselective C2-H alkylation of pyridines without the need of a C2-block. A wide range of pyridines, including unsubstituted pyridine, C3, C4, and C2-substituted pyridines, and even complex pyridine-containing bioactive molecules are well compatible with the reaction, providing up to 81% yield and up to 97% ee.
Topics & Concepts
ChemistryAlkylationEnantioselective synthesisBimetallic stripPyridineCatalysisYield (engineering)PhosphinePhosphine oxideOrganic chemistrySynergistic catalysisMedicinal chemistryCombinatorial chemistryMaterials scienceMetallurgyCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and Catalysis