Selectivity over coverage in <i>de novo</i> sequencing of IgGs
Maurits A. den Boer, Jean‐François Greisch, Sem Tamara, Albert Bondt, Albert J. R. Heck
Abstract
Generating protein sequence ladders of the CDR3 variable regions of antibodies facilitates <italic>de novo</italic> sequencing by mass spectrometry.
Topics & Concepts
Computational biologySequence (biology)DNA sequencingBiologyGeneticsGeneMonoclonal and Polyclonal Antibodies ResearchGlycosylation and Glycoproteins ResearchMass Spectrometry Techniques and Applications