A hypoxia-activatable theranostic agent with intrinsic endoplasmic reticulum affinity and type-I photosensitivity
Junqing Zhang, Yongkang Zhang, Hao Zhang, Wenhao Zhai, Xiaoqian Shi, Changhua Li
Abstract
applications. After intravenous administration to 4T1 tumor-bearing BALB/c mice, Im@NP demonstrated highly efficient imaging-guided PDT ablation of implanted tumors. This is because the delivered ERPSIm cargos of Im@NP are specifically activated in the hypoxic microenvironment of solid tumor, and the activated ERPS molecules have efficient ER-targeted type-I photosensitivity.
Topics & Concepts
Endoplasmic reticulumPhotosensitizerPhotosensitivityHypoxia (environmental)Cancer researchMaterials scienceBiophysicsChemistryMedicineBiologyBiochemistryPhotochemistryOrganic chemistryOptoelectronicsOxygenNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesAdvanced Nanomaterials in Catalysis