Bioconjugation of a Collagen-Mimicking Peptide Onto Poly(vinyl alcohol) Encourages Endothelialization While Minimizing Thrombosis
Novella M. Bates, Heather E. Heidenreich, Meghan E. Fallon, Yuan Yao, Evelyn K. F. Yim, Monica T. Hinds, Deirdre E.J. Anderson
Abstract
thrombosis assessment showed a reduction in platelet attachment and fibrin formation on GFPGER-modified PVA. Overall, GFPGER-modified PVA encouraged cell attachment while maintaining the material's hemocompatibility. This work is a significant step toward the development and characterization of a modified-hydrogel surface to improve endothelialization while reducing platelet attachment.
Topics & Concepts
BioconjugationVinyl alcoholPeptideChemistryBiochemistryOrganic chemistryPolymerProtease and Inhibitor MechanismsAngiogenesis and VEGF in CancerCell Adhesion Molecules Research