A clinically translatable kit for MRI/NMI dual-modality nanoprobes based on anchoring group-mediated radiolabeling
Lei Chen, Yun Gao, Jianxian Ge, Yi Zhou, Zhe Yang, Cang Li, Baoxing Huang, Kuan Lu, Dandan Kou, Dandan Zhou, Can Chen, Sixia Wang, Shuwang Wu, Jianfeng Zeng, Gang Huang, Mingyuan Gao
Abstract
nanoparticles sealed in the kit can well stand long-term storage even for 300 days without deteriorating the colloidal stability and radiolabeling yield. Upon intravenous injection of the as-prepared radiolabeled nanoprobes, high-resolution vascular images of mice were obtained by vascular SPECT imaging and magnetic resonance angiography, demonstrating the promising clinical translational value of our radiolabeling kit.
Topics & Concepts
Modality (human–computer interaction)MedicineNuclear medicineComputer scienceArtificial intelligenceNanoparticle-Based Drug DeliveryCharacterization and Applications of Magnetic NanoparticlesAdvanced biosensing and bioanalysis techniques