Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer
Huocong Huang, Zhaoning Wang, Yuqing Zhang, Rachana Pradhan, Debolina Ganguly, Raghav Chandra, Gilbert Z. Murimwa, Steven H. Wright, Xiaowu Gu, Ravikanth Maddipati, Sören Müller, Shannon J. Turley, Rolf A. Brekken
Abstract
T cells into regulatory T cells (Tregs) in an antigen-specific manner. Moreover, treatment with an antibody targeting the mesothelial cell marker mesothelin can effectively inhibit mesothelial cell to apCAF transition and Treg formation induced by apCAFs. Taken together, our study elucidates how mesothelial cells may contribute to immune evasion in pancreatic cancer and provides insight on strategies to enhance cancer immune therapy.
Topics & Concepts
Pancreatic cancerCancer researchMesothelial CellMesothelinBiologyImmune systemAntigenImmunologyCancerMedicinePathologyGeneticsPancreatic and Hepatic Oncology ResearchImmune cells in cancerSingle-cell and spatial transcriptomics