Cardiac telocytes inhibit cardiac microvascular endothelial cell apoptosis through exosomal miRNA-21-5p-targeted <i>cdip1</i> silencing to improve angiogenesis following myocardial infarction
Zhaofu Liao, Yilin Chen, Chuncui Duan, Kuikui Zhu, Ruijin Huang, Hui Zhao, Maik Hintze, Pu Qin, Ziqiang Yuan, Luocheng Lv, Hongyi Chen, Binglin Lai, Shanshan Feng, Xufeng Qi, Dongqing Cai
Abstract
silencing to improve angiogenesis in myocardial infarction. It is believed that these novel findings and the discovery of cellular and molecular mechanisms will provide new opportunities to tailor novel cardiac cell therapies and cell-free therapies for the functional and structural regeneration of the injured myocardium.
Topics & Concepts
AngiogenesisMicrovesiclesTherapeutic angiogenesisCancer researchMedicineParacrine signallingNeovascularizationApoptosisEndothelial stem cellGene silencingmicroRNAPathologyBiologyInternal medicineIn vitroReceptorGeneBiochemistryExtracellular vesicles in diseaseCircular RNAs in diseasesMicroRNA in disease regulation