Fatal exacerbation of ChadOx1-nCoV-19-induced thrombotic thrombocytopenia syndrome after initial successful therapy with intravenous immunoglobulins - a rational for monitoring immunoglobulin G levels
Jonathan Douxfils, Caroline Vayne, Claire Pouplard, Thomas Lecompte, Julien Favresse, Florence Potier, Emy Gasser, Valérie Mathieux, Jean‐Michel Dogné, Yves Gruel, Jérôme Rollin, François Mullier
Abstract
The present report describes a vaccine-induced thrombotic thrombocytopenia (VITT) case with fatal exacerbation after initial improvement following initial intravenous immunoglobulin (IVIg) administration and anticoagulation. An 83-year-old woman presented at the emergency room with an alteration of her general condition. She presented with symptoms of weakness, nausea, vomiting, weight loss and spontaneous bruises without any obvious reason, 14 days after having received her first dose of ChadOx1 nCov-19. [...]
Topics & Concepts
AntibodyIntravenous ImmunoglobulinsMedicineExacerbationImmunologyIntravenous Immunoglobulin TherapyHeparin-Induced Thrombocytopenia and ThrombosisPlatelet Disorders and TreatmentsComplement system in diseases