Pannexin 1 channels control the hemodynamic response to hypoxia by regulating O<sub>2</sub>-sensitive extracellular ATP in blood
Brett S. Kirby, Matthew A. Sparks, Eduardo R. Lazarowski, Denise A. Lopez Domowicz, Hongmei Zhu, T. McMahon
Abstract
Export of vasodilator ATP from red blood cells requires pannexin 1. Blood plasma ATP elevations in response to hypoxia in mice require pannexin 1. Hemodynamic responses to hypoxia are accompanied by increased plasma ATP in mice in vivo and require pannexin 1.
Topics & Concepts
PannexinHypoxia (environmental)ExtracellularHemodynamicsHaemodynamic responseVasodilationChemistryBiologyCell biologyInternal medicineOxygenEndocrinologyMedicineGap junctionHeart rateConnexinBlood pressureIntracellularOrganic chemistryNeuroscience of respiration and sleepConnexins and lens biologyHeme Oxygenase-1 and Carbon Monoxide