Evidence of shared transcriptomic dysregulation of HNRNPU-related disorder between human organoids and embryonic mice
Andrew K. Ressler, Gabriela L.A. Sampaio, Sarah A. Dugger, Tamar Sapir, Daniel Krizay, Michael J. Boland, Orly Reiner, David B. Goldstein
Abstract
-related disorder. Thus, hnRNPU deficient human organoids may only be suitable to model transcriptional dysregulation in certain cell types within a specific developmental time window.
Topics & Concepts
TranscriptomeOrganoidEmbryonic stem cellNeuroscienceDrug discoveryBiologyComputational biologyBioinformaticsGeneGene expressionGeneticsGenetics and Neurodevelopmental DisordersRNA Research and SplicingPluripotent Stem Cells Research