Sporadic Dissemination of <i>tet</i> (X3) and <i>tet</i> (X6) Mediated by Highly Diverse Plasmidomes among Livestock-Associated Acinetobacter
Ying-Ying Cheng, Yang Liu, Yong Chen, Fu-Man Huang, Rong-Chang Chen, Yong-Hong Xiao, Kai Zhou
Abstract
Recently identified plasmid-borne tet (X) genes have greatly challenged the efficiency of tigecycline, a last-resort antibiotic for severe infection, while the dissemination pattern of the plasmid-borne tet (X) genes remains unclear. In this study, we identified a clonal dissemination of tet (X3)-positive A. towneri isolates on a swine farm, while the tet (X6)-positive A. towneri strains mainly disseminated sporadically on the same farm.
Topics & Concepts
AcinetobacterBiologyAcinetobacter baumanniiPlasmidTigecyclineMicrobiologyContext (archaeology)GenBankStrain (injury)GeneAntibiotic resistancePhylogenetic treeHorizontal gene transferColistinGeneticsGenomeDrug resistanceEnterobacteriaceaeAntibiotic Resistance in BacteriaPharmaceutical and Antibiotic Environmental ImpactsAntimicrobial agents and applications