PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis
Shouqiao Hou, Jian Zhang, Xiaoyan Jiang, Yuanxin Yang, Bing Shan, Mengmeng Zhang, Cong Liu, Junying Yuan, Daichao Xu
Topics & Concepts
NecroptosisRIPK1BiologyCell biologyProgrammed cell deathSignal transducing adaptor proteinUbiquitinSignal transductionBiochemistryApoptosisGeneCell death mechanisms and regulationNuclear Structure and FunctionPARP inhibition in cancer therapy