PCSK9 attenuates efferocytosis in endothelial cells and promotes vascular aging
Shijie Liu, Jinzi Wu, Amanda J. Stolarz, Huiliang Zhang, Marjan Boerma, Stephanie D. Byrum, Nancy J. Rusch, Zufeng Ding
Abstract
These findings provide initial evidence for the ability of aortic ECs to accomplish efferocytosis and argue for a role of PCSK9 in attenuating EC efferocytosis, thereby leading to vascular dysfunction and acceleration in vascular aging.
Topics & Concepts
EfferocytosisThymoquinonePCSK9InflammationBiologyLDL receptorCell biologyInternal medicineMedicineImmunologyCancer researchPharmacologyEndocrinologyLipoproteinMacrophageCholesterolBiochemistryIn vitroAntioxidantPhagocytosis and Immune RegulationPancreatitis Pathology and TreatmentImmune cells in cancer