Tuning the properties of atomically precise gold nanoclusters for biolabeling and drug delivery
Manman Xu, Tongtong Jia, Bingjie Li, Wang Ma, Xiaoyuan Chen, Xueli Zhao, Shuang‐Quan Zang
Abstract
A structure-determined gold-levonorgestrel nanocluster, Au10(C21H27O2)10 (Au10NC), has been obtained via solvent induced crystal transformation from Au8(C21H27O2)8 (Au8NC), accompanied by a fluorescence color change from green to yellow. A cationic polymer, poly(allylamine hydrochloride) (PAH), was chosen to assemble with Au10NC to prepare monodisperse and stable particles (Au10NC-PAH) with an increased quantum yield of 49.8%. The as-fabricated Au10NC-PAH realized effective antibody-mediated actin imaging and sustained drug release.
Topics & Concepts
NanoclustersCationic polymerizationDrug deliveryNanotechnologyMaterials scienceDrugFluorescenceSolventPolymerTargeted drug deliveryChemistryPolymer chemistryOrganic chemistryPsychologyQuantum mechanicsComposite materialPhysicsPsychiatryNanocluster Synthesis and ApplicationsAdvanced Nanomaterials in CatalysisGold and Silver Nanoparticles Synthesis and Applications