Facile one-pot multicomponent synthesis of highly functionalized tetrahydropyridines using thiamine hydrochloride as an organocatalyst
Sandeep K. Singh, Annah Gupta, Kamal K. Kapoor
Abstract
Thiamine hydrochloride (VitB1) has been found to be an efficient catalyst for the multicomponent synthesis of highly functionalized tetrahydropyridines from the reaction of β-ketoester, aromatic aldehydes and anilines. VitB1 is easily available, cheap, and eco benign.
Topics & Concepts
ChemistryHydrochlorideCatalysisOrganic chemistryThiamineOne-pot synthesisCombinatorial chemistryMulticomponent Synthesis of HeterocyclesQuinazolinone synthesis and applicationsChemical Synthesis and Reactions