Penicillin Binding Proteins and β-Lactamases of Mycobacterium tuberculosis: Reexamination of the Historical Paradigm
Gaurav Kumar, Christos Galanis, Hunter R. Batchelder, Craig A. Townsend, Gyanu Lamichhane
Abstract
M. tuberculosis, the causative agent of tuberculosis, kills more humans than any other bacterium. β-lactams are the most widely used class of antibiotics to treat bacterial infections. Unlike in the historical model that describes the relationship between β-lactams and M. tuberculosis, we find that M. tuberculosis penicillin binding proteins are able to inactivate select β-lactams with high efficiency.
Topics & Concepts
Penicillin binding proteinsMycobacterium tuberculosisPeptidoglycanTuberculosisMicrobiologyAntibioticsPenicillinBiologyCephalosporinBacterial cell structureBacteriaEnzymeBiochemistryGeneticsMedicinePathologyAntibiotic Resistance in BacteriaAntimicrobial Resistance in StaphylococcusTuberculosis Research and Epidemiology