Predicting COVID-19 infection risk in people who are immunocompromised by antibody testing
Ratna Sari Wijaya, Marina Johnson, Nicola Campbell, Beth Stuart, Adam G. Kelly, Nicole Tipler, Tobias Menne, Matthew J. Ahearne, Victoria Willimott, Anna Bowzyk Al-Naeeb, Christopher P. Fox, Graham P. Collins, Ann O’Callaghan, Andrew Davies, David Goldblatt, Sean H. Lim
Abstract
People with blood cancers have an increased risk of severe COVID-19 disease despite booster vaccine doses.1 This group, like other disease groups at increased risk of severe COVID-19, includes individuals with highly heterogeneous immune responses to vaccination.2 Although vaccine response studies and population studies identify similar diseases and treatments associated with increased risk of severe COVID-19, a direct correlation between antibody levels after vaccination and infection risk has been difficult to define.