From the bottle: simple iron salts for the efficient synthesis of pyrrolidines <i>via</i> catalytic C–H bond amination
Wowa Stroek, Lilian Hoareau, Martin Albrecht
Abstract
, amination is fast and selective, (<30 min for 80% yield at 2 mol% loading), TONs up to 370 are reached with just 0.1 mol% catalyst, different functional groups are tolerated, and a variety of C-H bonds were activated.
Topics & Concepts
AminationCatalysisPyrrolidineChemistryYield (engineering)Organic chemistryMedicinal chemistryCombinatorial chemistryMaterials scienceMetallurgySynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis