Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR
Xinyu Xu, Jonas Kaindl, Mary J. Clark, Harald Hübner, Kunio Hirata, Roger K. Sunahara, Peter Gmeiner, Brian K. Kobilka, Xiangyu Liu
Topics & Concepts
NorepinephrineBiologyEpinephrineNeurotransmitterCatecholamineAdrenergic receptorAntagonistReceptorMetadynamicsEndocrinologyBiochemistryChemistryDopamineMolecular dynamicsComputational chemistryReceptor Mechanisms and SignalingNeuroscience and Neuropharmacology ResearchLipid Membrane Structure and Behavior