Integration of in vitro data from three dimensionally cultured HepaRG cells and physiologically based pharmacokinetic modeling for assessment of acetaminophen hepatotoxicity
Chi Zhang, Qiang Zhang, Jin Li, Lin Yu, Fengxiang Li, Weiwei Li, Yujie Li, Hui Peng, Jun Zhao, Paul L. Carmichael, Yunfang Wang, Shuangqing Peng, Jiabin Guo
Topics & Concepts
Physiologically based pharmacokinetic modellingIn vitroAcetaminophenChemistryPharmacologyIn silicoToxicityIn vitro toxicologyPharmacokineticsOrganoidBiochemistryBiologyCell biologyOrganic chemistryGeneDrug-Induced Hepatotoxicity and ProtectionLiver physiology and pathologyPharmacogenetics and Drug Metabolism