Discovery of novel 2-phenylamino-4-prolylpyrimidine derivatives as TRK/ALK dual inhibitors with promising antitumor effects
Tong Li, Changtao Li, Jing Yang, Ming Guo, Zhi Cao, Xinyu Wang, Nan Jiang, Xin Zhai
Topics & Concepts
ChemistryCytotoxicityTrk receptorTropomyosin receptor kinase AIn vitroIC50EnzymeStructure–activity relationshipPharmacologyDocking (animal)StereochemistryALK inhibitorBiochemistryCombinatorial chemistryReceptorCrizotinibNerve growth factorSurgeryMalignant pleural effusionNursingMedicinePleural effusionCytokine Signaling Pathways and InteractionsLung Cancer Treatments and MutationsCancer therapeutics and mechanisms