Cellular microRNAs target SARS-CoV-2 spike protein and restrict viral replication
Kishore Vaddadi, Chaitanya Gandikota, Chaoqun Huang, Yurong Liang, Lin Liu
Abstract
MicroRNAs can impact viruses either by directly interacting with the virus genome or by modulating host factors. We identified that cellular miRNAs regulate effective antiviral defense against SARS-CoV-2 via modulating spike protein expression, which may offer a potential candidate for antiviral therapy.
Topics & Concepts
microRNABiologyViral replicationRNAVirologyVirusViral pathogenesisGeneCoronavirusGenomeTissue tropismComputational biologyGeneticsTropismCoronavirus disease 2019 (COVID-19)MedicineDiseaseInfectious disease (medical specialty)PathologySARS-CoV-2 and COVID-19 ResearchMicroRNA in disease regulationAnimal Virus Infections Studies