Comparative Effects of Phenolic Extract As an Ointment Dosage Form in Inducing Wound Healing in Mice and β-sitosterol in Experimentally Induced Acute Wound Healing in Mice
Raghda Falah, Haitham Mahmood Kadhim, Raghda Hassan, S Guo, L Dipietro, A Gosain, L Dipietro, L Braiman-Wiksman, I Solomonik, R Spira, T Tennenbaum, P Wong, D Kitts, A Aljanaby, V Nour, I Trandafir, S Cosmulescu, D Marinova, F Ribarova, M Atanassova, S Chaudhary, O Ceska, C Ttu, P Warrington, M Ashwood-Smith, G Poulton, E Awe, S Banjoko, L Melguizo-Rodrguez, E De Luna-Bertos, J Ramos-Torrecillas, R Illescas-Montesa, V Costela-Ruiz, O Garca-Martnez, A Merecz-Sadowska, P Sitarek, E Kucharska, T Kowalczyk, K Zajdel, T Cegliski, R Zajdel, X Zhang, D Mosser, A Ghasemzadeh, N Ghasemzadeh, A Merecz-Sadowska, P Sitarek, E Kucharska, T Kowalczyk, K Zajdel, T Cegliski, R Zajdel, J Davidson, A Rao, E Prasad, S Deepthi, V Haritha, S Ramakrishna, K Madhusudan, M Surekha, Y Rao, D Bhowmik, H Gopinath, B Kumar, S Duraivel, K Kumar, J Dai, R Mumper, M Jorge, C Madjarof, A Ruiz, A Fernandes, R Rodrigues, I De Oliveira Sousa, M Foglio, J De Carvalho, B Reddy, R Reddy, V Naidu, K Madhusudhana, S Agwane, S Ramakrishna, P Diwan, P Betz, A Nerlich, J Wilske, J Tbel, R Penning, W Eisenmenger, S Cohen
Abstract
Background: Wound healing is a multi-phase and well-organized dynamic process involving the coordinated use of numerous cell types and biological processes to repair damaged tissue, which relies on many inter-related factors. The failure of traditional healing protocols in many cases of acute wound healing that may progress to gangrene or lead to chronic wounds and amputation provides a strong stimulus to discover a neoteric, relatively long-term, safe, and effective treatment. Antioxidant, anti-inflammatory, and anti-microbial mechanisms are used. As is widely known, plant secondary metabolites such as phenolic compounds, besides their beneficial impact on the plant host, can be effective for humans in treating a variety of disorders. The most common properties of polyphenols-antioxidant, anti-inflammatory, and antimicrobial-indicate that they deserve recognition in natural medicine and may be highly effective in the treatment of various skin problems. Those three mentioned properties constitute the main potential mechanisms of action against various skin disorders.