Chemistry and Biological Activities of 1,2,4-Triazolethiones—Antiviral and Anti-Infective Drugs
Ashraf A. Aly, Alaa A. Hassan, Maysa M. Makhlouf, Stefan Bräse
Abstract
Mercapto-substituted 1,2,4-triazoles are very interesting compounds as they play an important role in chemopreventive and chemotherapeutic effects on cancer. In recent decades, literature has been enriched with sulfur- and nitrogen-containing heterocycles which are used as a basic nucleus of different heterocyclic compounds with various biological applications in medicine and also occupy a huge part of natural products. Therefore, we shed, herein, more light on the synthesis of this interesting class and its application as a biologically active moiety. They might also be suitable as antiviral and anti-infective drugs.
Topics & Concepts
ChemistryMoietyBiological activityCombinatorial chemistryDrug discoveryComputational biologyBiochemistryOrganic chemistryBiologyIn vitroClick Chemistry and ApplicationsSynthesis and biological activitySynthesis and Characterization of Heterocyclic Compounds