Hsa_circ_0030042 regulates abnormal autophagy and protects atherosclerotic plaque stability by targeting eIF4A3
Fangpu Yu, Ya Zhang, Zunzhe Wang, Weigang Gong, Cheng Zhang
Abstract
These results demonstrate a novel pathway involving hsa_circ_0030042, eIF4A3, FOXO1, and beclin1; hence, modulating their levels may be a potential therapeutic strategy against CHD.
Topics & Concepts
AutophagyFlow cytometryBiologyTransfectionSmall interfering RNAIn vivoCancer researchIn vitroApoptosisMolecular biologyCell biologyChemistryCell cultureBiochemistryBiotechnologyGeneticsCircular RNAs in diseasesCancer-related molecular mechanisms researchMicroRNA in disease regulation