Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor microenvironment modulation
Lingjuan Chen, Hongqi Chen, Junjie Ye, Yan Ge, Haiyan Wang, Enyong Dai, Jinghua Ren, Weilin Liu, Congrong Ma, Songguang Ju, Z. Sheng Guo, Zuqiang Liu, David L. Bartlett
Abstract
Either secreted or membrane-bound IL-23-armed vaccinia virus can induce potent antitumor effects and IL-23 is a candidate cytokine to arm oncolytic viruses for cancer immunotherapy.
Topics & Concepts
Oncolytic virusTumor microenvironmentVacciniaImmunotherapyCancer researchBiologyCancer immunotherapyCancerVirotherapyImmunologyChemokineCancer cellImmune systemVirologyGeneGeneticsRecombinant DNABiochemistryVirus-based gene therapy researchCAR-T cell therapy researchViral Infectious Diseases and Gene Expression in Insects