Water enabled, nickel-catalyzed highly chemoselective <i>C</i>-allylation of (NH)-indoles employing alcohols
Gargi Nikhil Vaidya, Shyam Kumar Lokhande, Sangita Dattatray Shinde, Dinesh Parshuram Satpute, Garvita Narang, Dinesh Kumar
Abstract
The ‘in-water’ nickel-catalyzed chemoselective C 3 -allylation of (NH)-indoles employing allylic alcohols under mild conditions is reported.
Topics & Concepts
CatalysisAllylic rearrangementNickelChemistryOrganic chemistryCombinatorial chemistryCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisSynthesis of Indole Derivatives