Senescence of alveolar epithelial progenitor cells: a critical driver of lung fibrosis
Tanyalak Parimon, Peter Chen, Barry R. Stripp, Jiurong Liang, Dianhua Jiang, Paul W. Noble, William C. Parks, Changfu Yao
Abstract
With an aging population, lung fibrotic diseases are becoming a global health burden. Dysfunctional repair of the alveolar epithelium is a key causative process that initiates lung fibrosis. Normal alveolar regeneration relies on functional progenitor cells; however, the senescence of these cells, which increases with age, hinders their ability to contribute to repair. Here, we discuss studies on the control and consequence of progenitor cell senescence in fibrosis and opportunities for research.
Topics & Concepts
SenescenceProgenitor cellRegeneration (biology)FibrosisLungProgenitorPulmonary fibrosisStem cellMedicinePopulationPathologyImmunologyBiologyCell biologyInternal medicineEnvironmental healthNeonatal Respiratory Health ResearchInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisCongenital Diaphragmatic Hernia Studies