High clustering rate and genotypic drug-susceptibility screening for the newly recommended anti-tuberculosis drugs among global extensively drug-resistant <i>Mycobacterium tuberculosis</i> isolates
Kanwara Trisakul, Ditthawat Nonghanphithak, Pratchakan Chaiyachat, Orawee Kaewprasert, Kankanon Sakmongkoljit, Wipa Reechaipichitkul, Angkana Chaiprasert, David Blair, Taane G. Clark, Kiatichai Faksri
Abstract
genes, conferring resistance to cycloserine, were found in 153/513 isolates (29.8%). No known mutations associated with linezolid resistance were detected. Cluster analysis showed that 408/513 isolates fell within 99 clusters and that 354 of these isolates were possible primary drug-resistant TB (292 XDR-TB, 57 pre-XDR-TB and 5 MDR-TB). Clonal transmission of primary XDR isolates might contribute significantly to the high prevalence of DR-TB globally.
Topics & Concepts
ClofazimineBedaquilineDrug resistanceTuberculosisLinezolidMycobacterium tuberculosisExtensively drug-resistant tuberculosisGenotypeVirologyBiologyMultiple drug resistanceMicrobiologyMedicineGeneGeneticsVancomycinBacteriaImmunologyStaphylococcus aureusPathologyLeprosyTuberculosis Research and EpidemiologyMycobacterium research and diagnosisAntibiotic Resistance in Bacteria