A quantitative empirical directing group scale for selectivity in iridium-catalysed hydrogen isotope exchange reactions
Daria S. Timofeeva, David M. Lindsay, William J. Kerr, David J. Nelson
Abstract
Competition hydrogen isotope exchange (HIE) experiments are used to construct quantitative directing group scales for two catalysts; these can be used to predict the outcomes of HIE reactions of substrates with multiple directing groups.
Topics & Concepts
Hydrogen isotopeIridiumCatalysisSelectivityChemistryCompetition (biology)HydrogenKinetic isotope effectScale (ratio)Group (periodic table)IsotopeOrganic chemistryDeuteriumBiologyPhysicsEcologyQuantum mechanicsChemical Reactions and IsotopesChemical Synthesis and CharacterizationAsymmetric Hydrogenation and Catalysis