Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFR WT and EGFR T790M inhibitors

Tarfah Al‐Warhi, Ahmed A. Al‐Karmalawy, Ayman Abo Elmaaty, Maha A. Alshubramy, Marwa Abdel‐Motaal, Taghreed A. Majrashi, Medhat Asem, Ahmed Nabil, Wagdy M. Eldehna, Marwa Sharaky

2022Journal of Enzyme Inhibition and Medicinal Chemistry48 citationsDOI Open Access PDF

Abstract

were assessed for their EGFR kinase (Wild and T790M) inhibitory activities, revealing eligible potential. Additionally, molecular docking, ADME, and SAR studies were carried out for the investigated candidates.

Topics & Concepts

ADMEChemistrySuperoxide dismutaseApoptosisDocking (animal)T790MCell cycleBiochemistryEbselenPharmacologyCancer researchAntioxidantEpidermal growth factor receptorBiologyIn vitroGlutathione peroxidaseReceptorGefitinibMedicineNursingSynthesis and biological activityComputational Drug Discovery MethodsSynthesis and Characterization of Heterocyclic Compounds

Biological evaluation, docking studies, and <i>in silico</i> ADME prediction of some pyrimidine and pyridine derivatives as potential EGFR <sup>WT</sup> and EGFR <sup>T790M</sup> inhibitors

Abstract

Topics & Concepts