A General Metal‐Free Protocol for the Visible‐Light‐Driven Protection of Carbonyls
Lorenzo Di Terlizzi, Eirini M. Galathri, Stefano Protti, Christoforos G. Kokotos, Maurizio Fagnoni
Abstract
The protection of a carbonyl is a standard procedure to mask the reactivity of this group towards nucleophiles and reductants. The present work pointed out the potentialities of arylazo sulfones as non-ionic photoacid generators (PAGs) to promote the efficient conversion of aldehydes and ketones into acetals, ketals, and 1,3-oxazolidines upon visible-light irradiation. This approach employed mild conditions and exhibited an easy scalability and a broad scope (80 examples included).
Topics & Concepts
ChemistryVisible spectrumProtocol (science)PhotochemistryNanotechnologyCombinatorial chemistryMaterials scienceOptoelectronicsMedicineAlternative medicinePathologyChemical Synthesis and ReactionsMarine Toxins and Detection MethodsElectrochemical sensors and biosensors