Electrodimerization of <i>N</i>-Alkoxyamides for the Synthesis of Hydrazines
Abudulajiang Nasier, Xihao Chang, Chang Guo
Abstract
An efficient and valuable N–N dimerization reaction of N-alkoxyamides is reported under undivided electrolytic conditions. This electrochemical strategy provides a powerful way to access a wide range of advanced, highly functionalized hydrazines. Remarkably, an N-centered radical generated from the cleavage of the N–H bond under electrolytic conditions plays a crucial role in this transformation. Furthermore, various N-alkoxyamides bearing different substituents are suitable in this transformation, furnishing the corresponding hydrazines in up to 92% yield.
Topics & Concepts
Yield (engineering)ElectrochemistryBond cleavageChemistryTransformation (genetics)Cleavage (geology)Combinatorial chemistryElectrolyteMedicinal chemistryOrganic chemistryElectrodeMaterials scienceCatalysisMetallurgyPhysical chemistryBiochemistryGeneFracture (geology)Composite materialRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques