Fucoxanthin alleviated myocardial ischemia and reperfusion injury through inhibition of ferroptosis <i>via</i> the NRF2 signaling pathway
Jing Yan, Zehua Li, Liang Yu, Chaobo Yang, Wen Ou, Huaqiang Mo, Min Tang, Deshu Chen, Chongbin Zhong, Dongdong Que, Liyun Feng, Hua Xiao, Xudong Song, Pingzhen Yang
Abstract
FX stimulated NRF2 to ameliorate mitochondrial dysfunction and inhibit overloading ROS and Fe 2+ , which contribute to lipid peroxidation and thus lead to ferroptosis, alleviating MIRI.
Topics & Concepts
FucoxanthinMyocardial ischemiaReperfusion injurySignal transductionMyocardial Reperfusion InjuryPharmacologyIschemiaChemistryIschemic reperfusion injuryCell biologyMedicineCardiologyBiologyBiochemistryCarotenoidHormonal Regulation and HypertensionCircular RNAs in diseasesMicroRNA in disease regulation