HucMSC exosome-delivered 14-3-3ζ alleviates ultraviolet radiation-induced photodamage via SIRT1 pathway modulation
Peipei Wu, Bin Zhang, Xinye Han, Yaoxiang Sun, Zixuan Sun, Linli Li, Xinru Zhou, Qian Jin, Peiwen Fu, Wenrong Xu, Hui Qian
Abstract
-induced cytotoxic damage by inhibiting oxidative stress and promoting the activation of autophagy. Our study found that 14-3-3ζ protein, which was delivered by hucMSC-ex, exerted a cytoprotective function via the modulation of a SIRT1-dependent antioxidant pathway. Collectively, our findings indicated that hucMSC-ex might represent a new potential agent for preventing or treating UV radiation-induced skin photodamage and aging.
Topics & Concepts
ExosomeUltravioletUltraviolet radiationModulation (music)RadiationCell biologyChemistryOptoelectronicsMaterials scienceOpticsMicrovesiclesPhysicsBiologyBiochemistrymicroRNAAcousticsRadiochemistryGeneSirtuins and Resveratrol in MedicineGenomics, phytochemicals, and oxidative stressRedox biology and oxidative stress