NF-<i>κ</i>B: a mediator that promotes or inhibits angiogenesis in human diseases?
Yijing Jiang, Jie Zhang, Conglin Shi, X. Li, Yongying Jiang, Renfang Mao
Abstract
Abstract The nuclear factor of κ-light chain of enhancer-activated B cells (NF-κB) signaling pathway, which is conserved in invertebrates, plays a significant role in human diseases such as inflammation-related diseases and carcinogenesis. Angiogenesis refers to the growth of new capillary vessels derived from already existing capillaries and postcapillary venules. Maintaining normal angiogenesis and effective vascular function is a prerequisite for the stability of organ tissue function, and abnormal angiogenesis often leads to a variety of diseases. It has been suggested that NK- κ B signalling molecules under pathological conditions play an important role in vascular differentiation, proliferation, apoptosis and tumourigenesis by regulating the transcription of multiple target genes. Many NF- κ B inhibitors are being tested in clinical trials for cancer treatment and their effect on angiogenesis is summarised. In this review, we will summarise the role of NF- κ B signalling in various neovascular diseases, especially in tumours, and explore whether NF- κ B can be used as an attack target or activation medium to inhibit tumour angiogenesis.