Growth-coupled selection of synthetic modules to accelerate cell factory development
Enrico Orsi, Nico J. Claassens, Pablo I. Nikel, Steffen N. Lindner
Abstract
Synthetic biology has brought about a conceptual shift in our ability to redesign microbial metabolic networks. Combining metabolic pathway-modularization with growth-coupled selection schemes is a powerful tool that enables deep rewiring of the cell factories’ biochemistry for rational bioproduction.
Topics & Concepts
BioproductionModular programmingSynthetic biologySelection (genetic algorithm)Computer scienceBiochemical engineeringFactory (object-oriented programming)Metabolic pathwayComputational biologyComputer architectureBiologyBiotechnologyArtificial intelligenceEngineeringBiochemistryProgramming languageMetabolismMicrobial Metabolic Engineering and BioproductionViral Infectious Diseases and Gene Expression in InsectsGene Regulatory Network Analysis