The Role and Regulation of Pulmonary Artery Smooth Muscle Cells in Pulmonary Hypertension
Shixin He, Tengteng Zhu, Zhenfei Fang
Abstract
Pulmonary hypertension (PH) is one of the most devastating cardiovascular diseases worldwide and it draws much attention from numerous scientists. As an indispensable part of pulmonary artery, smooth muscle cells are worthy of being carefully investigated. To elucidate the pathogenesis of PH, several theories focusing on pulmonary artery smooth muscle cells (PASMC), such as hyperproliferation, resistance to apoptosis, and cancer theory, have been proposed and widely studied. Here, we tried to summarize the studies, concentrating on the role of PASMC in the development of PH, feasible molecular basis to intervene, and potential treatment to PH.
Topics & Concepts
Pulmonary arteryMedicinePulmonary hypertensionSmooth musclePathogenesisPulmonary cancerCardiologyInternal medicineCancerCancer researchPulmonary Hypertension Research and TreatmentsMicroRNA in disease regulationCardiovascular, Neuropeptides, and Oxidative Stress Research