Signaling mechanisms in renal compensatory hypertrophy revealed by multi-omics
Hiroaki Kikuchi, Chung‐Lin Chou, Chin‐Rang Yang, Lihe Chen, Hyun Jun Jung, Euijung Park, Kavee Limbutara, Benjamin C. Carter, Zhihong Yang, Julia Kun, Alan T. Remaley, Mark A. Knepper
Abstract
Loss of a kidney results in compensatory growth of the remaining kidney, a phenomenon of considerable clinical importance. However, the mechanisms involved are largely unknown. Here, we use a multi-omic approach in a unilateral nephrectomy model in male mice to identify signaling processes associated with renal compensatory hypertrophy, demonstrating that the lipid-activated transcription factor peroxisome proliferator-activated receptor alpha (PPARα) is an important determinant of proximal tubule cell size and is a likely mediator of compensatory proximal tubule hypertrophy.