Selection of DNA-encoded chemical libraries against endogenous membrane proteins on live cells
Yiran Huang, Ling Meng, Qigui Nie, Yu Zhou, Langdong Chen, Shilian Yang, Yi Man Eva Fung, Xiaomeng Li, Cen Huang, Yan Cao, Yizhou Li, Xiaoyu Li
Topics & Concepts
Drug discoveryMembrane proteinChemistryDNAChemical biologyHigh-throughput screeningChemical libraryComputational biologyFunction (biology)Ligand (biochemistry)Integral membrane proteinMembraneBiochemistryCell biologyReceptorBiologySmall moleculeAdvanced biosensing and bioanalysis techniquesChemical Synthesis and AnalysisClick Chemistry and Applications