Misexpression of genes lacking CpG islands drives degenerative changes during aging
Jun-Yeong Lee, Ian Davis, Elliot H. H. Youth, Jonghwan Kim, Gary A. Churchill, James W. Godwin, Ron Korstanje, Samuel J. Beck
Abstract
gene up-regulation is directly responsible for age-related physiological deterioration, notably for increased secretion of inflammatory mediators.
Topics & Concepts
BiologyCpG siteGeneCell biologyGeneticsGene expressionDNA methylationRNA Research and SplicingGenomics and Chromatin DynamicsDNA Repair Mechanisms