Enantioselective total synthesis of parnafungin A1 and 10a-<i>epi</i>-hirtusneanine
Jiawei Sun, Wei Gu, He Yang, Wenjun Tang
Abstract
The first, enantioselective total synthesis of the heterodimeric biaryl antifungal natural product parnafungin A1 as well as 10a-<italic>epi</italic>-hirtusneanine is accomplished, using a cross-coupling strategy to construct their sterically hindered biaryl cores.
Topics & Concepts
Enantioselective synthesisTotal synthesisSteric effectsNatural productAntifungalChemistryCombinatorial chemistryStereochemistryOrganic chemistryCatalysisBiologyMicrobiologyChemical synthesis and alkaloidsFungal Biology and ApplicationsMicrobial Natural Products and Biosynthesis