Three-component synthesis, utilization and biological activity of phosphinoyl-functionalized isoindolinones
Nóra Popovics-Tóth, Bettina Rávai, Ádám Tajti, Bence Varga, Péter Bagi, Franc Perdih, Pál Szabó, László Hackler, László G. Puskás, Erika Bálint
Abstract
A new approach for the synthesis of phosphinoyl-functionalized isoindolinones was developed. One product was utilized as a P-ligand in the synthesis of a platinum complex, and two derivatives showed promising activity against Gram positive bacteria.
Topics & Concepts
ChemistryComponent (thermodynamics)Combinatorial chemistryPhysicsThermodynamicsSynthesis and pharmacology of benzodiazepine derivativesPhosphorus compounds and reactionsMulticomponent Synthesis of Heterocycles